Losigamone: From Plant Extract to Antiepileptic Drug

Isobolographic analysis of interactions among losigamone analog AO-620 and two conventional antiepileptic drugs.

In the present study, we investigated pharmacodynamic interactions among AO-620, a losigamone analog, and two conventional antiepileptic drugs, valproate (VPA) and phenobarbital (PB). Experiments were conducted in the maximal electroshock test in mice. Isobolographic analysis of the obtained data revealed pure additive interactions between AO-620 and PB applied at three dose ratios of 1:1, 1:3 ...

Antiepileptic drug actions.

Antiepileptic drugs (AEDs) vary in their efficacy against generalized tonic-clonic, myoclonic, and absence seizures, suggesting different mechanisms of action. Phenytoin (PHT), carbamazepine (CBZ), and valproate (VPA) reduced the ability of mouse central neurons to sustain high-frequency repetitive firing of action potentials (SRF) at therapeutic free serum concentrations. Phenobarbital (PB) an...

A new antiepileptic drug.

Antiepileptic drug monitoring.

Normal and Abnornml De the Human Nervous Syste Lemire, J. D. Loeser, R. VN -.E. C. Alvord. (Pp. 421 $27.50.) Harper and Row USA. 1975. 'Fills a long-felt gap' is a viewers but the phrase is ii this book. In a clear an way it gathers together a of information about the and growth of the hun system and gives a brief the major developmental Standardised graphs pres formation in a manner rapid refe...

Plasticity of antiepileptic drug targets.

The mechanisms underlying the development of drug resistance in epilepsy are complex and, at this time, not fully understood. It is widely accepted that the efficacy of an antiepileptic drug (AED) is determined by its ability to cross the blood-brain barrier (BBB) and bind to intraparenchymal target sites. According to the target hypothesis, pharmacoresistance occurs when target sites are struc...